A comprehensive review of disclosures in academic journals regarding the synthesis of Rasagiline and its closely related compounds along with majorbiological activity advancements
Keywords:
Rasagiline, indane moiety, propargyl moiety, mesylation, resolution, synthesis, isolationAbstract
This review article was primarily focused to unwind the prior art disclosures about the synthetic strategies adopted for the preparation of Rasagiline and its closely related scaffolds. Additionally, some of the major biological activity advancements of Rasagiline and its derivatives were also given the priority. It was observed that, propargyl part/ indane part/ or both of Rasagiline was extended through numerous synthetic pathways to achieve enhanced biological activity. Additionally, numerous resolution routes were also executed to isolate the intended product with high chiral purity. Hence, this review contribution can be a good platform for the worldwide researchers to design new routes to synthesize Rasagiline and its structurally close resemblance derivatives.
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Copyright (c) 2024 Sanjay Sukumar Saralaya
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