Indian Journal of Pharmacy & Drugs Studies 2022-08-08T12:27:03-05:00 Dr. Rashmi Agrawal Open Journal Systems <pre><strong>Discipline:</strong> Pharmaceutical Sciences <br /><strong>Starting Year:</strong> 2020 <br /><strong>Current volume:</strong> Volume 3<br /><strong>Issue per year:</strong> 4 issues<br /><strong>Indexing: </strong>Google Scholar<br /><strong>E-mail: <a href="" target="_blank" rel="noopener"></a> </strong></pre> Pharmacovigilance study on the increased use of antibiotics in pediatric treatment 2022-06-07T17:22:47-05:00 Ghansham R Sakhare Purva Yelwande Sandhya Suryawanshi Kiran Ambhore Rutuja Pawar Kishor Jain <p>Objective: To conduct the pharmacovigilance study on the increased use of antibiotics in pediatric treatment. Materials and Methods: A suitable, simple questionnaire associated with the study of pharmacovigilance assessment, for mainly the adverse drug reactions associated with the increased antibiotic use in pediatric treatment was designed and distributed among 200 families having children in the age groups of &lt;1 to 8 year. This survey was done in Pune region. Amoxicillin, Tetracycline, Cephalexin, Doxycycline were the antibiotics selected for the study. Results: About self-medication more than 50% groups said they did self-medication. and major source for it was medicines leftover from previous prescriptions. Maximum response was obtained from 5–8year age group. ADR were detected with the usage of antibiotics in 66 percent of groups. When it comes to the intensity of an adverse drug reaction, 74% of respondents said it was light, 22% said it was moderate, and 4% said it was severe. Around 97 % groups said they went to doctor after occurrence of adverse drug reaction, 98 % percent groups said they were aware of the risks of self-medication. Majority of groups knew about adverse drug reactions reporting system. When it comes to awareness of increased antibiotic use leading to antibiotic resistance, 98% of groups were found aware of the problem. Discussion: Survey showed that families having small children experienced adverse drug reactions as a result of using any of the antibiotics Amoxicillin, Tetracycline, Cephalexin, or Doxycycline. Conclusion: In conclusion, our study strongly recommends that there is a great need to create awareness among the middleclass families having children to improve the reporting of ADR’s.</p> 2022-08-08T00:00:00-05:00 Copyright (c) 2022 Ghansham R Sakhare, Purva Yelwande, Sandhya Suryawanshi, Kiran Ambhore, Rutuja Pawar, Kishor Jain RP-HPLC Method Development and Validation for Simultaneous Estimation of Benidipine Hydrochloride and Chlorthalidone in Pharmaceutical Dosage Form 2022-07-19T12:52:32-05:00 Hasan Shaikhmulani Ashpak M Tamboli Naziya A Tamboli Rohan T Kshirsagar <p>A simple, precise, rapid and accurate reverse phase High Performance Liquid Chromatography (HPLC) method was developed for the estimation of Benidipine Hydrochloride and Chlorthalidone in bulk and tablet dosage form. C18 C-18Agilent Zorbax Bonus –RP (250 x 4.6 mm, Particle size -5 Micron) was used in this method. The mobile phase comprises of Methanol and 0.1% Orthophosphoric acid (45:55v/v) with flow rate 1 mL/min (Photodiode array Detector). The retention time for Benidipine Hydrochloride was 1.09 min and for Chlorthalidone was 3.52 min. The detection concentration was linear over 32-48 ?g/mL for Benidipine Hydrochloride and 100-150 ?g/mL for Chlorthalidone. The regression equation of Benidipine Hydrochloride and Chlorthalidone were found to be y = 50184x-30070 and y = 37102x-74642 respectively with regression co-efficient of Benidipine Hydrochloride and Chlorthalidone were 0.999 and 0.999. So, the present work is aimed for development of simple, reproducible chromatographic RP-HPLC method for simultaneous estimation of Benidipine Hydrochloride and Chlorthalidone. The developed method was successfully validated in accordance to ICH guideline. Hence the method can be conveniently adopted for routine analysis in quality control laboratories.</p> 2022-08-08T00:00:00-05:00 Copyright (c) 2022 Hasan Shaikhmulani, Ashpak M Tamboli, Naziya A Tamboli, Rohan T Kshirsagar