An overview of prior art disclosures about the synthesis of lamotrigine and a glimpse of its closely related compounds
Keywords:
Lamotrigine, Cyanation, Condensation, Cyclization, RecrystallizationAbstract
In this review contribution, we have gathered the specific details in brief from the prior art disclosures regarding the synthesis of 1 and its closely related compounds. The prior art disclosures were in the form of patent publications and academic journal articles. During the review process it was noticed that, most of the disclosures on the synthesis of 1 were in the form of patent publications. With an emphasis to enhance the physico-chemical properties of 1, a few crystal/co-crystal/ionic salts of 1 are reported mainly in the academic journal articles. The glimpses of some closely related compounds to 1 are also included in this review contribution. This initiative can provide a platform for the global researchers to get an insight into the disclosures towards the synthesis of 1 and a glimpse on its closely related scaffolds. Additionally, the researchers can design new routes to commercialize 1 in future with higher atom economy by adhering to the green chemistry principles.
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Copyright (c) 2024 Sanjay Sukumar Saralaya, Shashikumar Somashekar Hiriyalau
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