Evidence for immunothrombosis according to some markers of thromboinflammation in women with unexplained recurrent reproductive failures

Abstract

Background: Unexplained recurrent reproductive failures (URRF) is a term that describes three different conditions of infertility, namely unexplained infertility (UI), unexplained recurrent miscarriage,and unexplained recurrent implantation failures. It is a global reproductive health problem. The aim of the present study was to compare some systemic markers of thromboinflammation in women with URRF to controls. Materials and Methods: This was a case–control study involving 70 subjects (35 cases of URRF and 35 healthy control women). The systemic cellular markers of immunothrombosis involving the platelet count, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), neutrophil-to-lymphocyte ratio (NLR), and the platelet-to-lymphocyte ratio were determined using the Sysmex XN-10 Automated Hematology Analyzer, Sysmex Corporations Japan. Data were analyzed using one-way analysis of variance in GraphPad Prism version 8.0 (GraphPad Software, San Diego, CA, USA) and presented as mean±standard deviation. Statistical significance was defined as p<0.05. Results: The MPV, PDW, and NLR were significantly increased (p=0.002, 0.007, and 0.028), respectively, in the subjects with URRF compared to the healthy controls. Conclusion: This finding supports evidence for immunothrombosis in patients with URRF.