Formulation and Evaluation of Rapidly Dissolving Film containing Antihistaminic drugs (Levocetirizine dihydrochloride)

Authors

  • Vamakshi Thaker
  • Jyoti Verma
  • Suchita Waghmare
  • Navinraj Mourya

Keywords:

Orodispersible tablet, Surfactants, Levocetirizine dihydrochloride, Superdisintegrants

Abstract

The oral dispersible tablets of Levocetirizine dihydrochloride were prepared by direct compression method. Various combinations of Sodium Starch Glycolate (SSG), Croscarmellose sodium (CCS) and Crospovidone (CP) were used as superdisintegrants for formulating the oral dispersible. It was seen that increasing the concentration of the superdisintegrants decreased the wetting time and disintegration time of the formulations. The combination of SSG & CP was more effective in decreasing the disintegration time as compared to the combination of SSG & CCS and CP & CCS. The in-vitro dissolution study showed that the formulation containing SSG (6%) and CP (4.5%) was more effective in enhancing the rate of drug release from the oral dispersible tablets. The comparison of effect of individual superdisintegrant on wetting time, disintegration time and dissolution showed that SSG was more suitable for the formulation of oral dispersible tablets of Levocetirizine dihydrochloride as compared to other superdisintegrants used in the current study. Hence, from the present study, it can be concluded that the superdisintegrants SSG and CP in appropriate concentration can be used to develop oral dispersible tablets of Levocetirizine dihydrochloride by dire ct compression method.

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Published

2023-12-06

Issue

Section

Original Article

How to Cite

Formulation and Evaluation of Rapidly Dissolving Film containing Antihistaminic drugs (Levocetirizine dihydrochloride). (2023). Indian Journal of Pharmacy & Drug Studies, 2(1), 23-26. https://mansapublishers.com/index.php/ijpds/article/view/3542

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