Advances in Ocular Drug Delivery System for Glaucoma Management – A Comprehensive Review

Abstract

In today’s world delivery of ophthalmic drugs remains challenging despite easy accessibility via the ocular surface. Eye drops
are easy and most widely used for drug delivery for treating ocular infections, particularly involving the internal segment
having an additional benefit of avoiding first-pass metabolism there while passing through the systemic circulation. The
challenges of drug administration through traditional methods involve improper patient education for drug installation
techniques, compliance, adherence, and persistence. Different dynamic and static ocular barriers involved only permit limited
drug delivery to the target ocular tissues. In this review, we described the development of well-tolerated drug delivery systems
that helps to overcome the factors limiting adequate drug delivery to the glaucomatous patients targeting infected tissues with
traditional techniques.