Design and Development of Press Coated Pulsatile Release of KetoprofenTablets

Abstract

Ketoprofen pulsatile tablets were developed and evaluated in this work utilizing synthetic polymers
grades Hydroxy propyl methyl
cellulose ( HPMC) E5, HPMCE15, and natural polymer xanthan gum. The angle of repose and compressibility index were determined
to be within the acceptable range by pre formulation investigations of core tablet granules, demonstrating excellent flow properties for
compression. The core tablet underwent evaluation procedures that examined content homogeneity compliance, w eight fluctuation
within standard deviation (SD) ± 2%, hardness, and friability. Evaluations of the coated tablets showed that the weight fluct uation,
hardness, and friability all fell within SD ± 2%. In vitro dissolving tests were conducted on formulation s F1 through F9, and at the
conclusion of the sixth hour, formulation 8 produced a pulsatile drug release. After the allotted period, the medication was released
here at once. The stability study, which was conducted for two months for formulation 8 in acc ordance with International council of
Harmonisation ( ICH) requirements, was determined.