Multidrug Resistant Bacteria Causing Nosocomial Urinary Tract Infection in Neurology/ Neurosurgical Unit of a Tertiary Care Hospital

Abstract

Introduction: Nosocomial infections with the multidrug resistant microorganisms remain the major concern in the hospitalized patients. Due to the underlying illness, trauma, various neurosurgeries, patients admitted to neurology/ neurosurgery units become more vulnerable to acquire device associated infections during their hospital stay. Objectives: To study the spectrum of uropathogens and their antimicrobial susceptibility pattern among patients admitted to the neurology/neurosurgery unit. Material and methods: A prospective study was conducted in the bacteriology laboratory, Department of Microbiology over a period of 4 months. Urine samples from the patients admitted to neurology and neurosurgical unit (ward and ICU) were processed and identified as per the standard protocol. The antimicrobial susceptibility testing was done using Kirby- Bauer method as per CLSI 2014 guideline. Results: Majority of the urinary isolates belonged to Enterobacteriaceae family in both ward and ICU patients. Among these, 91 out of 106 (86%) isolates in the ward and 43 out of 51 (84%) isolates in ICU were found to be multi drug resistant. Nitrofurantoin was observed to be resistant in more than 75% of both ward and ICU isolates. Conclusion: Majority of nosocomial uropathogens were found to be multidrug resistant. This study emphasizes the emergence of MDR isolates and nitrofurantoin resistance among the nosocomial uropathogens.