Efficacy of Individualized Homoeopathic Medicines with Aided Therapy in Alzheimer’s Disease: A Retrospective Observational Study Using ADAS-Cog Scale

Abstract

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline, memory impairment, and functional deterioration. Existing pharmacological therapies provide only modest symptomatic relief and are often associated with adverse effects. Homoeopathy, when combined with structured cognitive-aided therapy, may offer a holistic and patient-centred alternative for improving cognitive outcomes. This study was done to evaluate the efficacy of individualized homoeopathic medicines combined with cognitive-aided therapy in improving cognitive functioning in mild to moderate Alzheimer’s disease, using the Alzheimer’s Disease Assessment Scale – Cognitive Subscale (ADAS-Cog) as the primary outcome measure. Materials and Methods: A retrospective observational study was conducted on 68 patients diagnosed with mild to moderate AD who underwent individualized homoeopathic treatment combined with weekly cognitive-aided therapy for six months. The ADAS-Cog scores were recorded at baseline and after the treatment period. Data analysis was performed using paired t-tests. Results: A significant reduction in ADAS-Cog scores was observed following treatment. Mean baseline score of 27.6 ± 4.3 decreased to 19.4 ± 3.9 after six months (p < 0.001), indicating cognitive improvement. Supportive observations suggested benefits in memory, orientation, verbal fluency, and overall engagement. Conclusion: Individualized homoeopathic medicines combined with cognitive-aided therapy can contribute to improved cognitive functioning in mild to moderate Alzheimer’s disease.