A Homeopathic Approach in the Management of Non Alcoholic Fatty Liver Disease (NAFLD): A Case Series

Abstract

Non alcoholic fatty liver disease (NAFLD) is a prevalent hepatic disorder characterized by excessive lipid accumulation in the liver, independent of alcohol consumption. It is also often associated with metabolic conditions like obesity and diabetes. Liver fibrosis is a major health issue that impacts approximately 100 million people globally, leading to significant morbidity and mortality. It is a common endpoint in many chronic liver diseases and it is characterized by the buildup of collagen and extracellular matrix due to ongoing liver damage. Both clinical and experimental studies indicate that oxidative stress (OS) plays a key role in the development of fibrosis. Furthermore, OS related molecules may serve as crucial mediators, driving the molecular and cellular mechanisms that facilitate the progression of liver fibrosis. This case series presents three patients with non alcoholic fatty liver disease (NAFLD) who were managed with homeopathic medications Andrographis Paniculata, Berberis Vulgaris and respective constitutional remedies like Calcarea Phoshoricum, Calcarea Carbonicum, etc. over a period of six months. The ultrasound findings showed varying degrees of hepatic steatosis. Patients had individual profiles based on which remedies were chosen. Andrographis Paniculata and Berberis Vulgaris were prescribed for hepatocellular toxicity, hypertrophy, and inflammation whereas Calcarea Phosphoricum, Calcarea Carbonicum, etc. were intended to improve functions relating to lipid metabolism, detoxification, and homeostasis. This treatment was evaluated using blood tests, imaging, and symptom relief. All three patients experienced a reduction in fatigue and improved digestion, which resulted in positive liver ultrasound and lipid profiles. Andrographis Paniculata and Berberis Vulgaris are very much known for their effects of liver protection, were more effective in the reduction of inflammation in the liver, and Calcarea Phosphoricum or Calcarea Carbonicum helped to balance metabolism. No side effects were reported. This suggests a potential efficacy of these homeopathic medicines in the treatment of NAFLD, thus worth investigating in larger cohorts. Given the absence of FDA approved treatments for NAFLD, further research is needed to assess the efficacy and long term benefits of homeopathy in treating NAFLD.