IgG4-related disease presenting as a pancreatic mass: A case report

Authors

  • Abdo Lutf
  • Anwar Ibrahi Joudeh
  • Salah M Mehdi

DOI:

https://doi.org/10.32677/ejms.v8i4.4451

Keywords:

Autoimmune disease, Immunoglobulin G4-related disease, Lymphadenopathy, Pancreatic mass, Steroids

Abstract

Immunoglobulin G4-related disease (IgG4-RD) is an increasingly recognized fibroinflammatory condition with characteristic clinical, serological, and histopathological features. It might involve any organ in the body with a special predilection for lymph nodes, salivary glands, the pancreas, and the retroperitoneum. Due to the non-specific features of the disease and the capability of mimicking many other medical conditions, the diagnosis of IgG4-RD could be delayed. Herin, we describe a case of a middle-aged man who presented with obstructive jaundice due to a pancreatic mass. Further evaluation revealed multiple cervical and inguinal lymphadenopathy, bilateral wedge-shaped lesions in the kidneys and substantial thickening of the aortic wall that was suggestive of aortitis/periaortitis. A histopathological examination of an inguinal lymph node showed increased infiltration of nodal immunoglobulin G4 (IgG4) plasma cells (>30/high-power field) with a high serum IgG4 immunoglobulin level. Based on that, the patient was diagnosed with IgG4-RD, and he was successfully treated with pulse steroid therapy with complete resolution of his symptoms and the radiological and laboratory findings. IgG4-RD is a protean condition with a large spectrum of clinical manifestations that could mimic many other serious medical conditions. Early recognition and management of immunosuppression are vital for complete recovery.

Downloads

Download data is not yet available.

Downloads

Published

2024-03-19

How to Cite

IgG4-related disease presenting as a pancreatic mass: A case report. (2024). Eastern Journal of Medical Sciences, 8(4), 62 64. https://doi.org/10.32677/ejms.v8i4.4451

Most read articles by the same author(s)

<< < 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 > >>