An unusual presentation of Krukenberg tumor in a young female patient: A case report
Keywords:
Cytokeratin 7, Cytokeratin 20, Immunohistochemistry, Krukenberg, Signet ring cell carcinomaAbstract
Krukenberg tumor is an uncommon metastatic tumor of the ovary. It usually presents in female with an average age of 45 years
and constitutes 1-2% of all ovarian neoplasms. 30% of all ovarian neoplasms occurring during childhood and adolescence are
malignant. A 22-year-old unmarried lady presented with painless abdominal distension with amenorrhea. On examination, 18-week
lump was palpable. This lump was firm to hard in consistency, non-tender, and mobile. On ultrasonography, bilateral ovarian
tumors were reported, with peritoneal free fluid. Laparotomy with right salpingo-oophorectomy and enucleation of left ovarian
mass was performed. Microscopic examination revealed bilateral signet ring cells carcinoma of the ovaries probably metastatic
origin with intact capsule. Tumor cells exhibited strong, diffuse immunopositivity for cytokeratin (CK) 7 and CK 20. Diagnosis of
Krukenberg tumor was made. Repeated endoscopic biopsy confirmed the diagnosis of signet ring cell carcinoma stomach. This case
is reported because of its rarity in younger age group, diagnostic dilemma, and poor prognosis.