Histomorphological study of gastric mucosal biopsy in dyspepetic patients and its association with Helicobacter pylori infection

Authors

  • Prachi
  • M Shanthi
  • Kasa Somsekhar

DOI:

https://doi.org/10.32677/EJMS.2020.v05.i04.004

Keywords:

Dyspepsia,, Endoscopy,, Giemsa, Helicobacter pylori,, Immunohistochemistry

Abstract

Background: The rationale of the study was to evaluate the morphological changes of chronic gastritis and its association with
Helicobacter pylori infection and the efficacy of hematoxylin and eosin (H & E) and Giemsa techniques in a limited set up which
helps in providing the vital data for subsequent treatment regimen. Materials and Methods: In this prospective study, 50 endoscopic
biopsies were obtained from dyspeptic patients from January 2016 to June 2017. The samples were fixed in 10% buffered formalin
and histopathological slides were prepared using paraffin blocks and subsequently stained with routine H & E and special stain
with Giemsa. Results: There was a male preponderance in the study with a ratio of 2.3:1; the mean age of patients was 37.59 years. Of
the 50 patients, 47 patients (94%) had chronic gastritis. Twenty-one out of 47 samples showed positivity for H. pylori with routine
H & E staining, which was confirmed with the modified Giemsa staining method. Conclusion: Our study highlights the association
of H. pylori in patients with functional dyspepsia and demonstrate the importance of cost-effective Giemsa staining which can be
practically applicable in Indian set-up for the detection of H. pylori.

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Published

2021-02-08

Issue

Section

Original Article

How to Cite

Histomorphological study of gastric mucosal biopsy in dyspepetic patients and its association with Helicobacter pylori infection. (2021). Eastern Journal of Medical Sciences, 5(4), 84-87. https://doi.org/10.32677/EJMS.2020.v05.i04.004

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