Detection of CMV DNA in intraocular fluid samples in patients clinically diagnosed with viral uveitis by molecular methods

Authors

  • Ayfer Yolcu
  • Nuran Karabulut
  • Sema Alacam
  • Mustafa Onel
  • Belgin Izgi
  • Ali Agacfidan

DOI:

https://doi.org/10.32677/EJMS.2019.v04.i03.001

Keywords:

Cytomegalovirus, CMV DNA, PCR, Uveitis

Abstract

Background: Latent Cytomegalovirus (CMV) infections may be reactive in consequence of immunosuppression. Recently, CMV-associated uveitis cases have also been reported in immunocompetent individuals. Aim: The aim of this study was to obtain epidemiological data by evaluating CMV DNA PCR results, clinical characteristics and risk factors of patients diagnosed with viral uveitis. Methods: Between the years 2011-2017, anterior chamber fluid samples of 35 patients with viral uveitis sent from the ophthalmology clinic to the Virology Laboratory were included in this study. CMV DNA real-time PCR results were evaluated. Results: CMV DNA positivity was detected in 9 (26%) of the 35 patients. CMV DNA positivity was highest (13%) in over 60 years (p=0.02). Acute recurrent uveitis in 44% (4/9) of patients, single eye involvement in 78% (7/9) and anterior uveitis in 44% (4/9) were found. Conclusion: In this study, CMV DNA positivity was detected in 26% of the patients with viral uveitis. Considering the presentations of a small number of cases related to CMV uveitis in our country, this study is important due to being the most comprehensive study in our country.

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Original Article

How to Cite

Detection of CMV DNA in intraocular fluid samples in patients clinically diagnosed with viral uveitis by molecular methods. (2019). Eastern Journal of Medical Sciences, 4(3), 106-111. https://doi.org/10.32677/EJMS.2019.v04.i03.001

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