A rare cause of neonatal seizure - Van der Knaap disease: A case report

Abstract

Van der Knaap disease is a rare genetic autosomal recessive disorder characterized by megalencephaly and leukodystrophy with subcortical cysts. In India, most of the cases reported are from a particular ethnic background (Agarwal) with consanguinity. Here, we are reporting a case not belonging to this ethnic background and born out of non-consanguineous marriage and who presented with a primary complaint of recurrent neonatal seizures.