Antibiogram resistance pattern of extended-spectrum beta-lactamase-positive bacterial isolates

Authors

  • B S Manjunath
  • E Adarsh
  • K V Rajanish
  • S Trupthi
  • C Niveditha
  • Darshan K Raj

DOI:

https://doi.org/10.32677/IJCH.2017.v04.i03.015

Keywords:

Antibiogram, Extended-spectrum Beta-lactamases, Escherichia coli

Abstract

Objectives: To identify the antibiogram resistance pattern of extended-spectrum beta-lactamase (ESBL)-positive bacterial isolates. Materials and Methods: This prospective, observational study was conducted in Rajarajeswari Medical College and Hospital, Bangalore, over a period of 12 months. The clinical samples were inoculated on the standard recommended media. Inoculated plates were incubated aerobically at 37°C for 24 h, and organisms were identified by culture and appropriate biochemical reactions. Antimicrobial sensitivity was performed by Kirby-Bauer disk diffusion method on Mueller-Hinton agar using commercially available antibiotic discs as per the Clinical and Laboratory Standards Institute Guidelines-2014. Results: Escherichia coli were the most common ESBL-producing organisms isolated from the study population accounting to 45% of the total cases. The next most common organisms were Klebsiella species and Pseudomonas. Ceftriaxone was the most commonly used empirical antibiotic (33.3% cases). Piperacillin and meropenem were used in combination with tazobactam or sulbactam, respectively, as per the culture and sensitivity reports. Conclusion: The association of change in antibiotic to mortality was found to have significance. The change in antibiotic in deterioration of the illness showed decrease in mortality.

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Published

2017-09-26

Issue

Section

Original Articles

How to Cite

Antibiogram resistance pattern of extended-spectrum beta-lactamase-positive bacterial isolates. (2017). Indian Journal of Child Health, 4(3), 341-344. https://doi.org/10.32677/IJCH.2017.v04.i03.015

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