Assessment of the efficacy of 400 IU of oral Vitamin D3 supplementation for term healthy breastfed Indian infants

Authors

  • Kaifi Siddiqui
  • Anwar Hasan Siddiqui
  • Sheeba Farooqui
  • Pradeep Kumar Ranbijuli

DOI:

https://doi.org/10.32677/IJCH.2021.v08.i03.004

Keywords:

Breastfed infants, New born, Sunlight exposure, Supplements, Vitamin D

Abstract

Introduction: Vitamin D is essential for growing children and its deficiency may have a catastrophic effect on growing children. Various reports state that Vitamin D deficiency is widely prevalent in the Indian population including infants and children. Objective: The objective of the study was to assess the efficacy of 400 IU of oral Vitamin D3 supplementation for term healthy breastfed Indian infants. Materials and Methods: The prospective, double-blinded cross-sectional study included 100 newborns divided into two randomized groups, A and B through a computer-generated program. Group A received 1 ml (400IU) Vitamin D drops daily for 3 months along with the breast milk whereas the Group B was only breastfed. Serum Vitamin D, Calcium, and alkaline phosphatase levels were measured in both the groups at birth and 3 months follow-up. Results: At birth no significant difference was observed in the serum level of Vitamin D, calcium and alkaline phosphatase in both the groups; however, at 3 month follow-up visit the Group A babies who were supplemented with Vitamin D 400 IU/day had a significantly more Vitamin D level (27.61 ± 11.95 ng/ml) compared with the babies of the non-supplemented group (10.56 ± 7.34 ng/ml). In the supplemented group, 46.7% had normal Vitamin D levels (>30 ng/ml), 20% had insufficiency (20–30 ng/ml) and 33.3% were deficient (<20 ng/ml). In babies who were non-supplemented, none had normal Vitamin D levels (>30 ng/ml), 13.3% had insufficiency (20–30 ng/ml), and 86.7% were deficient (<20 ng/ml). Group A babies also had significantly more serum calcium (9.81 ± 0.82 mg/dl) as compared to the Group B babies (8.52 ± 0.88). No significant difference was observed in alkaline phosphatase levels in both the group. Conclusion: In view of the high prevalence of maternal Vitamin D deficiency and the consequent low levels in the breast-fed infants do require supplementation of Vitamin D of at least 400 IU/day starting soon after birth.

Published

2021-04-02

How to Cite

Kaifi Siddiqui, Anwar Hasan Siddiqui, Sheeba Farooqui, & Pradeep Kumar Ranbijuli. (2021). Assessment of the efficacy of 400 IU of oral Vitamin D3 supplementation for term healthy breastfed Indian infants. Indian Journal of Child Health, 8(3), 122-126. https://doi.org/10.32677/IJCH.2021.v08.i03.004

Issue

Section

Original Articles