Intra-vesical BCG induced granulomatous hepatitis and disseminated Koch’s: Our experience

Authors

  • Rahul Ramdas Ghule
  • Subodh Ratnakar Shivde
  • Ram Naresh Daga

DOI:

https://doi.org/10.32677/IJCR.2017.v03.i01.014

Keywords:

Bacille Calmette-Guerin (BCG), Mycobacterium bovis strain, granulomatous hepatitis

Abstract

Bacille Calmette-Guerin (BCG) vaccine, developed by Calmette and Guerin at Institute Pasteur (Lille, France), is a live-attenuated Mycobacterium bovis strain. There are many therapeutic uses of the species have been described, Intravesical BCG has been established as an effective treatment of superficial bladder cancer. A 66-year old gentleman with newly diagnosed superficial high-grade papillary transitional cell carcinoma involving lamina propria (T1) of the bladder underwent 3 cycles of intravesical BCG. First 2 cycles were uneventful and tolerated well. After 3rd BCG cycle, patient developed granulomatous hepatitis with disseminated Koch's. BCG-induced sepsis after intra-vesical instillation for bladder cancer is a rare complication. Pathophysiology remains largely unknown, but BCG’s low virulence suggests that immunological hypersensitivity reaction probably plays a role. There have been no prospective studies to evaluate the optimal treatment for BCG infection.

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Published

2020-10-08

Issue

Section

Case Report

How to Cite

Intra-vesical BCG induced granulomatous hepatitis and disseminated Koch’s: Our experience. (2020). Indian Journal of Case Reports, 3(1), 47-49. https://doi.org/10.32677/IJCR.2017.v03.i01.014

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