A rare cause for delirium: COPE syndrome

Abstract

Calcium-alkali syndrome (CAS) (Milk alkali syndrome) is the third most common cause of hypercalcemia. The triad of hypercalcemia, metabolic alkalosis, and variable renal failure constitutes this syndrome. Here, we report a case of CAS in a female with post-thyroidectomy hypoparathyroidism who presented with delirium due to hypercalcemic encephalopathy. CAS can occur even after decades of normocalcemia in hypoparathyroidism, and regular monitoring of calcium levels is required.