Drug rash with eosinophilia and systemic symptoms syndrome in an elderly man on carbamazepine – A jeopardising clinical entity

Authors

  • Alna Merin George
  • Abdul Khader
  • Sarojiniamma CS

DOI:

https://doi.org/10.32677/ijcr.v8i11.3680

Keywords:

DRESS syndrome, Carbamazepine, RegiSCAR scoring system, mini-DRESS, skirt syndrome

Abstract

Drug rash with eosinophilia and systemic symptoms syndrome (DRESS) is a rare but serious hypersensitivity drug reaction most frequently associated with antiepileptics. We report a case of carbamazepine-induced DRESS syndrome in a 61-year-old man who was recently initiated on carbamazepine (6 weeks back) and presented with a history of acute febrile illness of 10 days duration. General examination showed multiple erythematous coalescent papules and rash over the body with relative sparing of the face with lymphadenopathy. Laboratory results revealed eosinophilia, atypical lymphocytosis, transaminitis, and negative serology for hepatitis. Registry of severe cutaneous adverse reactions (RegiSCAR) scoring system case is categorized as a definite case with a score of 7. Carbamazepine was discontinued and with the initiation of intravenous steroids; the transaminitis improved, fever and rashes resolved. We report a case of carbamazepine induced DRESS syndrome in a 61-year-old man. He was recently initiated on carbamazepine (6 weeks back), who presented to with a history of acute febrile illness of 10 days duration. General examination showed multiple erythematous coalescent papule and rash over the body with relative sparing of face with lymphadenopathy. Laboratory results revealed an eosinophilia, atypical lymphocytosis, transaminitis and negative serology for hepatitis. RegiSCAR scoring system was used our case is categorized as definite case with a score of 7. Carbamazepine was discontinued and with initiation of intravenous steroids; the transaminitis improved, fever and rashes resolved.

Downloads

Download data is not yet available.

Downloads

Published

2024-01-29

Issue

Section

Case Report

How to Cite

Drug rash with eosinophilia and systemic symptoms syndrome in an elderly man on carbamazepine – A jeopardising clinical entity. (2024). Indian Journal of Case Reports, 8(11), 347-350. https://doi.org/10.32677/ijcr.v8i11.3680

Most read articles by the same author(s)

<< < 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 > >>