An interesting case of masculine voice in a girl: A case report of 11 beta hydroxylase deficiency

Authors

  • Haritha Galla
  • M N Satya Vani

DOI:

https://doi.org/10.32677/IJCH.2021.v08.i07.003

Keywords:

Ambiguous genitalia, Hypertension, Voice change

Abstract

A 7-year-old girl presented to our outpatient department (OPD) with masculine voice, hyperpigmentation of skin, and genital ambiguity. On clinical examination, she had hypertension, hyperpigmentation of skin, pubarche, clitoromegaly, and low-pitched voice. Karyotype was 46 XX and ultrasound showed bilateral enlarged adrenals, uterus, and ovaries. Hormonal workup revealed elevated levels of 17-?-hydroxyprogesterone, testosterone, 11-deoxycortisol, and deoxycorticosterone. Due to the presence of hypertension, genital ambiguity and elevated 11-deoxycortisol, a diagnosis of 11-?-hydroxylase deficiency variant of Congenital Adrenal Hyperplasia was made. The child was started on hydrocortisone and amlodipine after which her symptoms such as hyperpigmentation improved.

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Published

2021-06-27

Issue

Section

Case Reports

How to Cite

An interesting case of masculine voice in a girl: A case report of 11 beta hydroxylase deficiency. (2021). Indian Journal of Child Health, 8(7), 246-248. https://doi.org/10.32677/IJCH.2021.v08.i07.003

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