Effect of Vitamin D on clinical profile of sickled children: A prospective study

Authors

  • Prakash Chandra Panda
  • Nihar Ranjan Mishra
  • Bichitra Nanda Sa
  • Amlan Khatua
  • Sumit Kumar
  • Bijan Kumar Nayak

DOI:

https://doi.org/10.32677/IJCH.2020.v07.i04.003

Keywords:

Duration of hospitalizations, Duration of pain hours, Number of vaso-occlusive crisis, Prospective study, Sickle cell anemia, Vitamin D

Abstract

Background: Vitamin D status in sickle cell children (SC) has been widely discussed and its effect on clinical profile among SC is currently highly debatable. Objective: The objective of this study was to determine the clinical outcomes in terms of morbidities for Vitamin D supplementation among Vitamin D deficiency (VDD) SC. Materials and Methods: A total of 428 children as per predefined inclusion and exclusion criteria were enrolled in this present prospective study, after receiving written informed parental consent. Patients were supplemented with Vitamin D according to their serum status and followed up at 3 subsequent visits (0, 6, and 12 weeks). All the relevant statistics were done by SPSS v 25.0 (IBM, New York). Results: A total of 428 diagnosed cases of sickle cell anemia were enrolled, from which 272 (63.6%) were male and 156 (36.4%) were female, and 393 cases were found to be VDD (92%). The mean age of the study population was 88.39 (46.27) months. Vitamin D supplementation was significantly associated with decrease in number of vaso-occlusive crisis, duration of hospitalization, and duration of pain hours (p<0.05). Conclusion: Vitamin D supplementation among sickled children with Vitamin D deficiency has a positive effect on its clinical parameters.

Downloads

Download data is not yet available.

Downloads

Published

2020-04-26

Issue

Section

Original Articles

How to Cite

Effect of Vitamin D on clinical profile of sickled children: A prospective study. (2020). Indian Journal of Child Health, 7(4), 148-151. https://doi.org/10.32677/IJCH.2020.v07.i04.003

Most read articles by the same author(s)

1 2 > >>