Primary schwannoma of the appendix: A rare case report with brief review of literature

Abstract

Appendiceal schwannoma is an exceptionally rare benign mesenchymal tumor and frequently poses a diagnostic 
challenge due to non-specific clinical and radiological findings. We report a case of appendiceal schwannoma in 
a 40-year-old female who presented with right iliac fossa pain and was clinically and radiologically suspected to 
have appendiceal carcinoma. Laparoscopic radical appendicectomy was performed. Histopathological examination 
revealed a spindle cell neoplasm with nuclear palisading, and immunohistochemistry showed diffuse strong SOX10 
positivity with negativity for CD117 and H-caldesmon, confirming the diagnosis. The patient remains asymptomatic 
on follow-up. A brief review of reported cases is provided.