Indian Journal of Child Health <pre><strong>ISSN:</strong> <strong>p-ISSN</strong> - 2349-6118; <strong>e-ISSN</strong> - 2349-6126 <br /><strong>Discipline:</strong> Pediatrics and Neonatology<br /><strong>Starting Year:</strong> 2014<br /><strong>Current volume:</strong> Volume 7<br /><strong>Issue per year:</strong> 12 (monthly)<br /><strong>Editor-in-chief:</strong> Dr. Girish Chandra Bhatt, India<br /><strong>Indexing:</strong> Index Copernicus, EZB, BASE, World Cat, Journal Guide, Google Scholar<br /><strong>E-mail: <a href="" target="_blank" rel="noopener"></a> </strong></pre> Mansa STM Publishers en-US Indian Journal of Child Health 2349-6118 Epidemiological and clinical profile of COVID-positive children without comorbidities: Observations from a dedicated COVID hospital in East India <p>Objective: The objective of the study was to study the epidemiological and clinical profile of COVID-positive children without pre-existing comorbidities at a dedicated COVID care hospital in the eastern state of Jharkhand. Materials and Methods: This retrospective study was conducted at a COVID hospital of the eastern state of Jharkhand on children up to 18 years of age admitted between May 2020 and October 2020. The case files of all children, with a positive reverse transcription polymerase chain reaction (RTPCR) report for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, were reviewed, and among them, all children without comorbidities were enrolled and studied. Relevant demographic details, clinical presentation, examination findings, investigations, and treatment received, were collected. Results: Out of 70 children enrolled in the study, 41 were male with a sex ratio of 1.4:1 and a median age (interquartile range) of 14 (8–16.5) years. About 94.2% of children had a history of contact with a positive member from their own family. About 14.2% had a history of travel to an endemic zone. About 34.2% of children were completely asymptomatic and in rest of the children, cough (23.8%) followed by fever (20.0%) was the most predominant complaint. Most of the symptomatic children had mild disease (62.8%). There was no mortality and all children were successfully discharged. The mean duration of disease (based on RTPCR status) was significantly lower in children up to 12 years of age in comparison to those older than 12 years. Conclusion: Family transmission is the major source of SARS-CoV-2 infection in children. Children can also serve as potential source of spread of infection in community. Age was the most important determinant of early recovery in pediatric population without comorbidities.</p> Abhishek Kumar Nilu Kumari Ranjeet Kumar Singh Singh V K Copyright (c) 2021 2021-06-03 2021-06-03 8 5 180 182 A prospective cross-sectional study of thyroid dysfunction in transfusion- dependent beta-thalassemia patients <p>Objective: The objective of the study was to determine the hospital-based prevalence of thyroid dysfunction in transfusion-dependent beta-thalassemia in children and to study the correlation between serum ferritin levels and thyroid functions. Methods: This prospective cross-sectional study in transfusion-dependent thalassemia patients was conducted in the department of pediatrics of a teaching hospital in India. General and systemic examinations were done and recorded and hemoglobin (Hb)%, thyroid-stimulating hormone (TSH), T3, T4, free thyroxin 4 (FT4), serum ferritin, and anti-thyroid peroxidase (TPO) levels were estimated in the laboratory. Initially, the estimation of Hb, TSH, T3, T4, and serum ferritin was done for all the study participants. Later, the specific values of FT4 and anti-TPO were estimated in study participants with high TSH values. Results: Fifty beta-thalassemia children aged between 3 and 18 years were chosen in this study. The prevalence of subclinical hypothyroidism was 6% and no cases of clinical or central hypothyroidism were found. The mean serum ferritin level was 2671 ± 1592 ng/ml; however, no positive correlation between serum ferritin and TSH values was seen. Conclusion: In thalassemia patients, the thyroid failure usually occurs by the second decade of their life. It is important that all beta-thalassemia children should undergo annual screening of thyroid functions in addition to detection of their serum ferritin levels.</p> Channanayaka Chandrashekhar Manovihari Vuyyuru Prajwala Hassan Vasudev George Mathew Panachiyil Tirin Babu Copyright (c) 2021 2021-06-03 2021-06-03 8 5 183 186 Comparison of serum biochemical parameters in children with febrile seizures <p>Background: Febrile convulsions are the most common provoked seizures affecting children. Low magnesium level leads to cell and membrane excitability thereby causing seizures. Objective: The objective of the study was to determine the role of serum sodium, calcium, magnesium, and zinc in children with simple febrile seizures (SFSs). Materials and Methods: This was a case–control study done in children admitted in the pediatric ward. Children with SFSs were taken as cases while children with fever but without seizures served as controls. After obtaining informed consent, details of each child were recorded, which included age, sex, seizure details (duration, type), nature of the febrile illness, and history of febrile seizures (FSs). Estimation of serum sodium, zinc, magnesium, and calcium was done. Results: The present study included 120 subjects, out of which 60 were cases and 60 were controls. The male-to-female ratio was 2:1. In our study, there was no significant difference in the levels of calcium, magnesium, and zinc in cases with FSs and controls. Although the serum zinc levels were in the normal range, majority of the children with SFS had serum zinc levels toward the lower range of normal which was statistically highly significant. Conclusion: Our study found that SFSs occurred more frequently in boys. The levels of serum calcium and magnesium were normal and did not correlate with SFS. Low serum zinc level had a direct correlation with SFS, although this level was within the defined normal range.</p> Gaurang Dilipkumar Pabani Pragya Prakash Chandra Khanna Copyright (c) 2021 2021-06-03 2021-06-03 8 5 187 189 Risk factors and outcome of malformations of gastrointestinal tract in neonates in a tertiary care center in India <p>Objective: The objective of the study was to determine the prevalence and associated risk factors of malformations of the gastrointestinal tract (MGIT) in neonates in a tertiary care hospital. Methods: We conducted a prospective, observational, case–control study on all intramural neonates till discharge/outcome for 1 year. Babies with MGIT diagnosed antenatally or postnatally were taken as cases and two consecutively born healthy babies were taken as controls. Results: Out of 25,116 live births, there were 41 cases of MGIT with a prevalence of 1.63 per 1000 live births. Tracheoesophageal fistula was the most common (39.02%), followed by anal atresia (24.39 %), esophageal atresia (9.46%), and mesenteric cyst (7.31%). Antenatally and postnatally, 16 (39.1%) and 25 (60.9%) cases were diagnosed, respectively. A significant association was observed between MGIT and lack of periconceptional iron/folic acid supplementation, birth weight &lt;2.5 kg, maternal age &gt;30 years, low socioeconomic profile, consanguinity, febrile illness in first trimester, and gender. The average time to onset of first feed and mean duration of hospital stay in babies with MGIT were 7 days and 14 days, respectively. Conclusion: Most MGIT can be diagnosed clinically and radiologically before/soon after birth and have a good outcome with timely surgical intervention. Pre-pregnancy counseling for periconceptional folic acid supplementation with screening ultrasonography, appropriate follow-up, and referral system should be developed for the management of these cases. A coordinated multidisciplinary approach for prevention, management, and rehabilitation of affected babies is required.</p> Shobhna Gupta Krishan Kumar Novy Gupte Deepak Bagga R. M. Pandey Harish Chellani Copyright (c) 2021 2021-06-03 2021-06-03 8 5 190 193 Congenital autosomal recessive cutis laxa 2A <p>Congenital cutis laxa is a rare inherited skin disorder and shows diverse phenotypic features among its different variants. Most forms are progressive and dysmorphic features worsen with age giving an appearance of early ageing. Autosomal recessive cutis laxa, type 2a, (ARCLIIa) is the only variant where phenotypic features undergo spontaneous regression and self-resolution with age. We are reporting a case of congenital ARCLIIa, in a child who had primarily presented with right-sided pneumonia. The child was investigated and worked up for cutis laxa based on skin appearance and characteristic facies (loose sagging skin, redundant skin folds, and hound-like facies). In view of history of a cousin having similar findings which had self-resolved overtime without any treatment, we further suspected it to be type 2A variant, which was proven by genetic analysis (ATP6V02 gene). Hence, we wish to report this case.</p> Sonia Karapurkar Parag Patel Bhumika Mishra Arpita Thakkar Mona Gajre Copyright (c) 2021 2021-06-03 2021-06-03 8 5 198 199 Clinical characteristics of neurological manifestations in influenza-A (H1N1) among children in a tertiary care hospital, South India, during 2019 <p>Objective: The objective of the study was to study the neurological manifestations of influenza-A in children. Materials and Methods: This retrospective study was conducted in a tertiary care hospital in South India during the seasonal epidemic of flu in 2019. All children aged 1 month–12 years with evidence of neurological manifestations and positive nasopharyngeal swab for influenza A were evaluated for the clinical features, treatment, and outcome. Results: Sixteen patients had neurological manifestations and 44% of them were &lt;2 years of age. The most common manifestations in this cohort was altered sensorium (87.5%) followed by seizures (62.5%). Fourteen patients developed symptoms within 5 days of onset. Only two children had cerebrospinal fluid pleocytosis and five children had abnormal neuroimaging findings. Intensive care management was required for 81% of children and the cause specific mortality was 18.75%. Conclusion: Neurological manifestation in influenza-A should be considered in children during epidemics and intensive care management can go a long way in improving the survival rates.</p> Sankar Vaikom Hariharan Rishika Jothi Perumalsamy Sheeja Sugunan Riaz Ismail A Santhoshkumar Copyright (c) 2021 2021-06-03 2021-06-03 8 5 194 197 Venous Thromboembolism and Infection in a child with Nephrotic Syndrome: Dangerous interplay of Old enemies <p>Venous thrombosis a known complication of Nephrotic syndrome. High IgE levels are commonly seen in children with Nephrotic syndrome. High IgE levels at the onset of Nephrotic syndrome with sepsis are risk factors for venous thromboembolism. We present through this a severe case of venous thromboembolism and sepsis in a child with Nephrotic syndrome.</p> Neha Bhandari Suprita Kalra Sheikh Muzaffar Sanjeev Khera Copyright (c) 2021 2021-06-03 2021-06-03 8 5 200 201