Eastern Journal of Medical Sciences 2022-07-23T13:53:25+0530 Sayan Bhattacharyya Open Journal Systems <pre><strong>ISSN: e-ISSN</strong> - 2456- 2785<br /><strong>Discipline:</strong> All Medical, Surgical and Dental Specialities<br /><strong>Starting Year:</strong> 2016<br /><strong>Current volume:</strong> Volume 7<br /><strong>Issue per year:</strong> 4 issues<br /><strong>Editor-in-chief:</strong> Dr. Sayan Bhattacharyya, India<br /><strong>Indexing:</strong> Index Copernicus, Journal Guide, Research Bible, World Cat, Sherpa Romeo, Google Scholar<br /><strong>E-mail: <a href="" target="_blank" rel="noopener"></a> </strong></pre> Decoding atypical laryngeal growths – A case report 2022-03-05T11:45:22+0530 MEGHNA DUTTA ABHIK GHOSH SUDDHASATWYA CHATTERJEE Enam Murshed Khan <p>Respiratory&nbsp; papillomatosis&nbsp; is&nbsp; a&nbsp; relatively&nbsp; rare&nbsp; disease&nbsp; with&nbsp; a&nbsp; potential&nbsp; for&nbsp; devastating&nbsp; consequences.&nbsp; The&nbsp; viral&nbsp; etiology&nbsp; of&nbsp; this&nbsp; condition&nbsp; has&nbsp; been&nbsp; well&nbsp; established.&nbsp; Most&nbsp; often,&nbsp; the&nbsp; wart&nbsp; is&nbsp; successfully&nbsp; managed&nbsp; surgically.&nbsp; Post&nbsp; surgical&nbsp; removal,&nbsp; there&nbsp; exists&nbsp; a&nbsp; high&nbsp; chance&nbsp; of&nbsp; recurrence&nbsp; of&nbsp; the&nbsp; papilloma.&nbsp; It&nbsp; has&nbsp; been&nbsp; documented&nbsp; that&nbsp; surgical&nbsp; removal&nbsp; followed&nbsp; by&nbsp; an&nbsp; adjuvant&nbsp; therapy&nbsp; helps&nbsp; to&nbsp; delay&nbsp; the&nbsp; recurrence.&nbsp; Also,&nbsp; the&nbsp; use&nbsp; of&nbsp; quadrivalent&nbsp; human&nbsp; papillomavirus&nbsp; vaccine&nbsp; is&nbsp; expected&nbsp; to&nbsp; decrease&nbsp; the&nbsp; incidence&nbsp; of&nbsp; respiratory&nbsp; papillomatosis&nbsp; or&nbsp; help&nbsp; with&nbsp; treatment&nbsp; of&nbsp; the&nbsp; disease&nbsp; in&nbsp; the&nbsp; years&nbsp; to&nbsp; come.&nbsp; Here&nbsp; we&nbsp; discuss&nbsp; an&nbsp; unusually&nbsp; late&nbsp; presentation&nbsp; of&nbsp; adult-onset&nbsp; laryngeal&nbsp; papilloma&nbsp; that&nbsp; was&nbsp; managed&nbsp; with&nbsp; some&nbsp; deviation&nbsp; from&nbsp; the&nbsp; routine.</p> 2022-07-23T00:00:00+0530 Copyright (c) 2022 MEGHNA DUTTA, ABHIK GHOSH, SUDDHASATWYA CHATTERJEE, Enam Murshed Khan Acute disseminated encephalomyelitis post-SARS-COV-2 vaccination with Chadox1 nCov-19 (AZD1222) – A rare case report 2022-03-05T07:48:09+0530 Meghna Sivji Vidya MV Thara Pratap Muhammed Jasim Abdul Jalal <p>Background: Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the CNS, characterized by fulminant multifocal neurologic injury and distinct neuropathologic findings.</p> <p>Case Report: We report a case of a forty-nine-year-old female who presented with progressive weakness of right side of the body of one-week duration. Clinical, laboratory and radiological features favored demyelination. There was temporal association with taking SARS COV 2 vaccination (ChAdOx1 n cov -19 (AZD1222)). She was treated with a course of steroids and made a good recovery.</p> <p>Conclusion: To our knowledge this is a rare case of ADEM noticed after ChAdOx1 nCoV-19 vaccine (AZD1222).</p> 2022-07-23T00:00:00+0530 Copyright (c) 2022 Meghna Sivji, Vidya MV, Thara Pratap, Muhammed Jasim Abdul Jalal The effect of geraniol dressing obtained from rose oil wound healing in diabetic rats 2022-01-05T00:15:28+0530 Sıddıka Ersoy Aynur Türeyen Ayşe Kocabiyik Yeliz Arman Karakaya <p class="MsoNormal" style="text-align: justify; text-indent: 21.0pt; line-height: 200%; tab-stops: 7.1pt;">Introduction: Diabetic foot is one of the most important chronic complications of diabetes mellitus. In this study, the aim was to investigate the healing effect of dressing with geraniol material obtained from rose oil. Materials and Methods: The experimental period of the study was carried out between June 2, 2016, and 27, 2016. Sprague-Dawley rats were used and three experimental, two control groups were formed. In the study conducted with a total of 40 rats, each group consisted of eight rats. Geraniol dressing, isotonic wet dressing, and hydrocolloid wound dressing were applied topically once a day to the first, second, and third groups, respectively. No dressing was applied to the positive and negative control groups. Index of oxidative stress of wound healing was assessed by total antioxidant status/total oxidant status measurements. Results: Due to the macroscopic results, it was determined that wound score was significantly decreased on day 3 in the first group and non-diabetic groups compared with other groups. When the microscopic findings were compared with day 0, in the first group, significant decrease of the level of collagen density and epithelization was observed on day 10. In the first group, increase in fat cells had become significant than other groups. In the CD34, SMA and vimentin staining, the first group showed superiority to other dressings. In the last measurements, the highest drop was seen in geraniol dressed and negative control groups. Conclusion: According to the study, geraniol dressed group provided similar wound healing with negative control group and showed superiority to the other products used as a standard in wound care.</p> 2022-07-23T00:00:00+0530 Copyright (c) 2022 S?dd?ka Ersoy, Aynur Türeyen, Ay?e Kocabiyik, Yeliz Arman Karakaya Soluble ST2 and its relation to inflammatory, vascular atherosclerotic, and calcification markers in patients with atrial fibrillation or heart failure at moderate-to-high cardiovascular risk 2022-05-30T12:21:03+0530 Yoto Trifonov Yotov Atanas Angelov Atanasov Milena Gincheva Pasheva Daniela Ivanova Gerova Bistra Tzaneva Galunska <p>Background: Cardiovascular diseases (CVDs) are the major cause of death globally. Among them, heart failure (HF) and atrial fibrillation (AF) result in poor prognosis and quality of life. Standard methods for assessing AF and HF, through history and physical examination, have limited sensitivity and specificity, which lead to delayed diagnosis and high risk of mortality. The identification of biomarkers able to detect the early stages of disease and/or their progression is of great importance for improving the clinical outcome. As AF and HF often coexist, it would be of great importance to find a biomarker with diagnostic utility in predicting HF in AF patients. Soluble suppression of tumorigenesis-2 (sST2) is a part of the cardioprotective IL-33/ST2 signaling pathway and may serve as a candidate biomarker for HF and AF. We aimed to evaluate sST2 serum levels in patients with AF and HF with preserved ejection fraction (HFpEF) and to explore potential relationships with traditional CVD risk factors and with novel biomarkers for vascular calcification such as undercarboxylated matrix Gla-protein (ucMGP). Materials and Methods: This study included 99 patients stratified into three groups: HFpEF (n=19), paroxysmal or persistent AF in sinus rhythm (n=33), and control group without CVD but at moderate-to-high CVD risk (n=47). Hemodynamic and anthropometric measures, coronary artery calcification (CAC), routine laboratory parameters, circulating ucMGP, and sST2 were measured. Results: sST2 levels were highly elevated in HFpEF patients. Significant positive correlation was found between sST2 and CAC-score (r=0.237, p=0.039), negative relations with serum lipids in AF patients, and positive association with serum C-reactive protein (r=0.609, p=0.018) in HFpEF patients. Soluble ST2 positively correlates with ucMGP in the entire studied population (r=0.252, p=0.006) and in the combined CVD group (AF+HFpEF) (r=0.254, p=0.036). Conclusions: sST2 levels emerge as a novel biomarker in CVD and may have prognostic importance for HF prediction in AF patients.</p> 2022-07-23T00:00:00+0530 Copyright (c) 2022 Yoto Trifonov Yotov, Atanas Angelov Atanasov, Milena Gincheva Pasheva, Daniela Ivanova Gerova, Bistra Tzaneva Galunska